Is there a connection?
I stumbled upon these Windhams by doing some web searches on www.google.com. The original web page I found seems to have disappeared now, but it indicated the fathers of each person. Here is a similar page that appears to be the same folks:

http://www.genealogy.com/users/s/n/e/Herman-Wayne-Snell/FILE/0001text.txt

Here they are:

Thomas Wyndham (? - ?), m. Susan CLERE (? - ?)

  1? Edward WINDHAM (1608 - Nov 1664)
     BIRTH: 1608, Norfolk, England 
     DEATH: Nov 1664, Norfolk, England 
     m. Abigail OFFLEY ()

     1? Edward Windham (? - ?)

        1? Reuben WINDHAM (? - 1745)
           BIRTH: Isle of Wight, VA 
           DEATH: 1745, Isle of Wight, VA 

	   1? Charles Windham (1709 - 1771)
              BIRTH: 1709, Isle of Wight, VA 
              DEATH: 1771, Cheraw Dist, SC 
              m. Mary (? - ?)

	      1? Amos WINDHAM (11 Nov 1741 - 21 Apr 1798)
                 BIRTH: 11 Nov 1741, Craven County, SC 
                 DEATH: 21 Apr 1798, Darlington Dist, SC 
		 m. Sarah MCHUGO (? - ?) f. William McHugo (? - ?)

		 1? John WINDHAM (ABT. 1775 - 1831)
                    BIRTH: ABT. 1775, Cheraw Dist, SC 
                    DEATH: 1831, Ewell, Dale County, AL 
		    m. Virginia Jane Mixon (1793 - 1860)
                       BIRTH: 1793, Darlington Dist, SC 
                       DEATH: 1860, Ewell, Dale County, AL 

		    1? Samuel WINDHAM (3 Sep 1813 - 3 Dec 1890)